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GenomeLab™ GeXP Genetic Analysis System, 110 V, 60 Hz, Dual Plate Format

Part Number: A26572

The GenomeLab™ GeXP Genetic Analysis System is a versatile platform capable of a multitude of genetic analysis applications from quantitative multiplexed gene expression to sequencing and fragment analysis. As a quantitative, high-throughput, multiplexed gene expression profiling solution, it has a capacity to analyze up to 30 genes/reaction/well with unrivaled sensitivity. The GeXP can quantitatively detect small, biologically relevant changes in gene expression, as low as 0.5 fold, with high accuracy. The GeXP platform is scalable, enabling the monitoring of tens to hundreds of genes for up to tens of thousands of samples. The readout can be efficiently used to look at focused sets of genes using very small amounts, as little as 5-50 ng of total RNA, accommodating varied quality of RNA.

The GenomeLab™ GeXP is also a fully automated, high-throughput sequencing and genotyping/fragment analysis system. In a single setup with one gel and one capillary array within the same plate, short templates are sequenced rapidly, long templates are sequenced faster with high quality reads, DNA fragments are sized accurately, and analyzed quantitatively with high-sensitivity and reproducibility.

Fragment analysis applications include:

SNP Scoring
Microsatellite Instability (STR)
MLPA
Loss of Heterozygosity
AFLP Fingerprinting

System Includes:

GenomeLab™ GeXP Separation Module
GenomeLab™ Controller
GeXP Software Package
eXpress Profiler PC
Two Flat-panel Monitors
Integrated bar code reader
2 x 96-well sample microplate format
Complete with Windows XP and Office 2007 installed
In-lab installation and training
User’s Guide

Quantity:

Specifications

UNSPSC:

41115811

Features

Gene Expression Features Include:
»	Capacity to analyze up to 30 genes/reaction/well
»	eXpress Designer tool, built on Primer 3 Software, to design primers and develop multiplexes using accession numbers
»	Evaluate primer sequences using BLAST searches
»	eXpress Analysis tool to couple experimental and sample information with capillary electrophoresis data, linking it to plate layout and project design
»	Automatically maps peaks with associated genes and calculates the relative gene expression values
»	Presents data in formats such as color grid and heat map, line plot, correlation and K-means plot analysis
»	Uses a patented highly multiplexed approach to quickly and efficiently analyze the expression of multiplexed gene sets with greater sensitivity and speed

The GenomeLab™ eXpress Profiler Suite takes the uncertainty out of assay design by providing fast, automated primer design and multiplex development, calculation of relative gene expression values and data checking, and first pass data analysis. This software suite includes eXpress Designer, eXpress Analysis, and eXpress Map.
»	eXpress Designer automates gene expression assay design with fast, in-lab primer design and multiplex development
»	eXpress Analysis calculates relative gene expression values, checks data, and performs a first-pass data analysis
»	eXpress Map provides the means to view the data in a number of formats, including line plots, correlation, K-means plots and color grid/heat map.
Pre-formulated, ready-to-use GenomeLab™ GeXP Reagent kits optimized for effortless and robust qualitative gene expression are available. The kits include reagents for discovery and master mix reagents for multiplexing

Applications for Gene Expression Include:
»	Discovery of Gene Targets
»	Pathway Analysis
»	Biomarker Discovery
»	Microarray Data Validation
»	RNAi Studies
»	Drug Characterization
»	Development of Signatures
»	Monitoring Gene Regulation

The GenomeLab™ GeXP Genetic Analysis System is Capable of Other Applications: Allele Identification, SNP Scoring, Microsatellite Instability, AFLP Fingerprinting, Loss of Heterozygosity, De Novo DNA Sequencing, Heterozygote Detection, Confirmatory Sequencing, Mutation Analysis. Key Features of the GenomeLab GeXP Genetic Analysis System:
»	Software tools for primer design and multiplex development as well as data and project management
»	Automatic switching from gene expression to fragment analysis to sequencing on the same plate without user intervention
»	Coated eight capillary array format
»	Integrated bar code reader
»	2 x 96-well sample microplate
»	Automatic linear polyacrylamide (LPA) gel replenishment, sample denaturation and injection
»	Four-wavelength laser-induced fluorescence detection

Consumables

285489	GenomeLab™ GeXP (One Rail) Fragment Analysis START-UP-PAC
608000	GenomeLab™ Methods Development Kit
285441	GenomeLab™ GeXP (One Rail) Sequencing START-UP-PAC
608082	Sample Loading Solution, SLS, 6.0 mL
608010	Separation Gel, 10 mL
391438	Separation Gel, for Dual Plate GeXP and CEQ™ 8800 Systems (20 mL)
608012	Buffer, Separation, GenomeLab™ Sequencing (pkg of 4)
607530	Cover Assembly, Buffer Evaporation
608070	Test Sample, DNA, (pkg of 3 vials)
608074	Sequencing Reaction Buffer (pkg of 12 vials)