Genetic Analysis—Applications

Since the first publication of the DNA double helical structure, electrophoresis has been a standard among the analytical tools used for nucleic acid analysis. Capillary electrophoresis (CE) technology extends the power of electrophoresis by incorporating direct detection, automation and the ability to study interactions in solution.

The following applications are routinely performed on the Beckman Coulter CE-based genetic analysis systems.

• GeXP series applications (capillary array technology)
  • Gene expression
  • Automated fragment sizing and allele identification
  • Single nucleotide polymorphisms (SNP)
  • Short tandem repeat (STR) analysis
  • Amplified fragment length polymorphisms
  • Quantitation / Loss of Heterozygosity
  • Automated heterozygote detection
  • Dye terminator cycle sequencing
  • Automated generation of locus tags - Binning
• P/ACE MDQ applications (single capillary technology)
  • Oligonucleotide purity
  • Plasmid analysis
  • Quantitation by direct hybridization
  • Single stranded conformational polymorphism (SSCP) analysis