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T3 Update On-Line--September 2005
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In this seventh on-line issue of T3 Update we provide Beckman Coulter users of Automated Solutions with Tips, Tricks and Techniques for Academic and Drug Discovery Research.

 Click here to download a printable version of the T3 Update On-Line (PDF Format, 2.95 MB).

From the Editor: 

In this issue, I am proud to share with you the positive impact of the recent acquisition of Agencourt Bioscience Corporation of Beverly, MA. As indicated in the two press releases, Beckman Coulter acquired Agencourt Bioscience to gain access to SPRI® technology. SPRI, which stands for Solid Phase Reversible Immobilization, is an enabling technology for Nucleic Acid sample prep.  more

Application Information

Genomics

  • Press Releases related to the Agencourt Biosciences acquisition
    • Beckman Coulter to Acquire Agencourt Bioscience Company to Gain enabling technology for nucleic acid sample preparation (Beckman Coulter Press Release). more
    • Agencourt Bioscience to be Acquired by Beckman Coulter. Wholly-Owned Subsidiary to Continue to Focus on Genomic Services and Reagent Solutions (Agencourt Bioscience Press Release). more
    • Beckman Coulter acquired Agencourt Bioscience to obtain access to their SPRI® technology. Solid Phase Reversible Immobilization (SPRI) is a patented, high performance nucleic acid purification technology invented at the Whitehead Institute (Hawkins, et al. Nucleic Acids Res. 1995; 23:22) Read more about SPRI Cutting Edge Magnetic Bead Technology. more 
  • Agencourt Applications
    • CleanSEQ® for Use with the ABI PRISM 3100 (Agencourt Application Note). more
    • CleanSEQ Dye-Terminator Removal Protocol.  more
    • Automation of Microarray Sample Processing Using Magnetic Bead-Based SPRI Technology, by Brian Packard, Erik Gustafson, Heather Ebling and Kevin McKernan, Agencourt Bioscience Corporation, Beverly, MA. more
    • RNA and cDNA Purification Using RNAClean™ (Agencourt Application Note). more
    • RNAClean In Vitro Produced RNA and cDNA Purification Protocol. more
    • SeeSNP™ Proprietary Analysis Advantages, by Kevin McKernan, Jim Yang, Betty Woolf, Rey Sequerra, Kathy Makowski and Tom Tang, Agencourt Biosciences Corporation, Beverly, MA. more 
    • To view additional information on Agencourt products and services, please visit the Agencourt website at www.agencourt.com.

Proteomics

  • NanoOrange* Protein Quantitation with the Beckman Coulter DTX 800/880 Multimode Detector, by K. Oender, H. Hintner and J.W. Bauer, Universitatsklinik fur Dermatologie, Paracelsus Medizinische Privat-Universitat; and H. Hundsberger, Beckman Coulter-Anthos Labtec Instruments. more

Cellular Analysis

  • Automated Multiplexing of Promega's Cell-Based Assays with Beckman Coulter Biomek FX and DTX 880 Multimode Detector, by Tracy Worzella and Brad Larson, Promega Corp (Madison, WI); Dave Daniels, Beckman Coulter, Inc. (Fullerton, CA). more

Automation Product Updates

  • Biomek ATBCR – Bob Lund describes the new Biomek Automated Tube Bar Code Reader (ATBCR) that allows the processing of open-top, tube-based samples and controls for reformatting to 96-well plates on the deck of a Biomek NX or FX platform with Span-8 functionality. more
  • Biomek Fly-By Bar Code Reader – Bob Lund describes the new Biomek Fly-By Bar Code Reader that allows for the initial reading of a sample bar code or allows for confirmatory bar code reading, conducted "on-the-fly" during a method. This reader can be used on any Biomek NX or FX platform with a gripper functionality to scan a single plate or a stack of up to 4 microplates. more
  • Labware Stacking ALP – Bob Lund describes a new accessory for Biomek NX Span-8 gripper platforms that provides "on-deck" sequential storage of Biomek tips, microplates, filtration blocks and other labware. more
  • Biomek P30XL Tips – Bob Lund describes new extended length tips that are supported on the Biomek NX, FX and Multimek® AP systems configured with 384-multichannel heads. more
  • BRT Robotic Transport – The Integrated Solutions team provides you updated information and availability of the BRT Robotic Transport product first described in the December, 2004 issue of T3 Update. more

Integrated Solutions

  • Biomek Multichannel Tip Pipetting. This custom solution utilizes a 96- or 384- channel head to enable users to perform serial dilutions in either single or multiple columns or rows. This solution is available on both the Biomek FX and NX and consists of both custom software steps and custom multichannel Pod Receivers. more
  • Beckman Coulter specification for Integration of Variomag Teleshake on SAGIAN™ Core System. The Variomag Teleshake is a microplate plate shaker sold by H+P that has been integrated by Beckman Coulter, Inc. onto a SAGIAN Core System using SILAS™ integration technology. more
  • Beckman Coulter K.K. (Japan) introduces the Super UHTS Robot E (S.U.R.E.) series Ψ 4 Workstation. The system, based on the Biomek FX, incorporates a number of custom modules built by IS Technology, Inc. (Tsukuba, Japan) and utilizes the latest version of SAMI scheduling software. more

Project Management -- North American Operations (NAO)

  • The customer presented the Project Management team with the need to automate a sample dilution series to enable them to run IC50 experiments using their ELISA protocols for QC testing of their products. Alisa Jackson describes the solution employed. more
  • The customer, a drug safety group within a major Pharmaceutical Company, presented the project management team with a need to automate their processes that involved the assessment of toxicology of their new drug candidates. Alisa Jackson describes the solution. more
  • The customer, a researcher in a major Canadian University, presented the Project Management team with a need to have walk away automation for the determination of impact of toxins on microbial growth over time. Mendy Van Deusen describes the Core System solution. more

Frequently Asked Questions

SAMI® Tips and Tricks
Question: My Print & Apply barcode printing station offers a lot of choices for printing different types of barcodes. However, I use the "Barcode Assign" module in my method to generate a virtual barcode for my assay plate. The final readout is done off line and I would like to print this virtual barcode onto my plate. How can I do this?
Answer: more

SAMI® Tips and Tricks
Question: By default, all data generated on one reader during one SAMI run will be logged in one single ASCII test file. We do kinetic reads in our assay and read the same plate several times. For easier data analysis, I would like to generate one log file per plate with all read outs for this one plate in the same file. Is this possible?
Answer: more

Question: How do I get involved in the ongoing discussion about automation using the Biomek laboratory automation platforms?
Answer: Join the Biomek User Forum, a forum for users of Beckman Coulter's Biomek laboratory automation workstations to discuss applications and exchange ideas with other users. more

Question: I would like to improve my confidence in pipetting techniques on the Biomek liquid handling platforms. What do you recommend?
Answer: View the Biomek Pipetting Guidelines. more

Tradeshow Participation in 2005-2006

Beckman Coulter Events Calendar more

* All trademarks are the property of their respective owners. Where applicable, the PCR process is covered by patents owned by Roche Molecular Systems, Inc., and F. Hoffmann-LaRoche, Ltd.

For comments or questions about T3 Update, please contact David Daniels, Ph.D., editor.

 
 
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