A Suite of Sedimentation Equilibrium/Velocity and Utilities Software

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SEDANAL: Software for the Analysis of Interacting and Non-interacting Macromolecular Systems by AUC (Analytical Ultracentrifugation)

Authored by: Dr. Walter Stafford

Available at:

• http://sedanal.bbri.org

SEDANAL can fit both sedimentation velocity and sedimentation equilibrium data and can handle nearly any arbitrary reaction scheme, including isodesmic, and isoenthalpic, indefinite self-associations. Both rapidly reversible and kinetically limited reactions can be modeled to determine molar masses, equilibrium constants, kinetic constants and stoichiometries.

A Model Editor program is used to create and maintain a database of models that are used by the main SEDANAL fitting routine.

SEDANAL comprises several programs including

1. A preprocessor for editing data and establishing radial positions.
2. A fitter that can fit either sedimentation equilibrium to sums of exponentials or sedimentation velocity time difference data to numerical solutions of the Lamm equation, using the models created with the ModelEditor.
3. DCDT for model independent treatment of sedimentation velocity data.
4. BIOSPIN, the analysis program developed by Roark and Yphantis for model independent treatment of sedimentation equilibrium data.

An extensive indexed SEDANAL Users' Manual is included.

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