Study establishes pediatric reference intervals for 47 hematologic parameters

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In a study published in American Journal of Clinical Pathology, fresh whole blood samples were collected from 566 healthy children and adolescents (birth to <21 years). The samples were analyzed for 47 hematologic parameters on the Beckman Coulter DxH 900. Age- and sex-specific reference standards were calculated based on the Clinical and Laboratory Standards Institute guidelines.

The study’s findings:

  • Established a robust database of pediatric reference standards for 47 hematologic parameters in the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) cohort for the first time
  • Along with accompanying publication containing hematologic Reference Intervals (RIs) on the Beckman Coulter DxH 9001, have the potential to address gaps in pediatric RIs for hematologic parameters and, as a result, improve the accuracy of laboratory result interpretation and clinical decision making in children and adolescents

At a Glance

566
Healthy children and adolescents (birth to <21 years)
47
Hematologic parameters were established with age- and sex-specific reference intervals
1 st
Comprehensive CALIPER study to establish hematologic RIs on the DxH 900, as well as develop RIs for emerging hematologic biomarkers, including the novel early sepsis indicator, MDW

Source: Tahmasebi, H., Higgins, V., Bohn, M. K., Hall, A., & Adeli, K. (2020, June 20). CALIPER Hematology Reference Standards (I): Improving Laboratory Test Interpretation in Children (Beckman Coulter DxH 900–Core Laboratory Hematology System). Oxford Academic, American Journal of Clinical Pathology. https://academic.oup.com/ajcp/article-abstract/154/3/330/5860205?redirectedFrom=PDF.

References:

1. Higgins V, Tahmasebi H, Bohn MK, et al. CALIPER hematology reference standards (II): improving laboratory test interpretation in children (Beckman Coulter DxH 520–Physician Office Hematology System) with analytical comparison to the Beckman Coulter DxH 900. Am J Clin Pathol. 2020; DOI: 10.1093/ajcp/aqaa057.