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Early Sepsis Detection

The global healthcare impact of sepsis

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis is a global healthcare crisis, affecting over 26 million people worldwide each year.1 The occurrence of sepsis is increasing at an annual rate of 1.5%, making it a significant global healthcare concern. Sepsis has a high mortality rate, killing more individuals than prostate cancer, breast cancer and HIV/AIDS combined.2,3,4 

In addition to the human toll, sepsis is costly to healthcare organizations. Sepsis-related costs—which may include longer hospital stays, ICU admissions, hospital readmissions, and extensive testing and patient monitoring—surpass $24 billion.


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Early detection and treatment can save lives 

Mortality from sepsis is decreased by 7.6% per hour by the early and appropriate administration of antibiotics.9 Early identification and treatment of sepsis can also reduce the cost of sepsis-related care.10,11

ED clinicians play a unique role as the first line of care for acutely ill patients. While the ability to triage patients, identify sepsis and initiate treatment is vitally important, diagnosing sepsis remains a challenge. Symptoms are often unclear and unspecific, such that sepsis is often overlooked or recognized too late.

Supporting Early Sepsis Detection 

Discover important information supporting early sepsis detection and timely patient care

Improved Early Detection of Sepsis in the ED With a Novel Monocyte Distribution Width Biomarker

“Sepsis most often presents to the ED, and delayed detection is harmful. WBC count is often used to detect sepsis, but changes in WBC count size also correspond to sepsis. We sought to determine if volume increases of circulating immune cells add value to the WBC count for early sepsis detection in the ED.”  

Get Answers with the ESCAVO Sepsis Clinical Guide app

The top-ranked app on the topic of sepsis, the ESCAVO Sepsis Clinical Guide is a medical reference mobile app for healthcare professionals managing patients in the acute-care setting. With the Sepsis Clinical Guide, clinicians access the latest research material in a user-friendly format, putting the most current clinical practice guidelines in their hands at the point of care.

Additional Resource

For more information about sepsis, visit Global Sepsis Alliance
Global Sepsis Alliance


1. Sepsis Alliance. “Critical Fact Sheet.” Sepsis.org. Accessed 15 Jan. 2018.
2. Vidant Beaufort Hospital “The Third-leading Cause of Death: Sepsis” www.thewashingtondailynews.com/2017/07/08/the-third-leading-cause-of-death-sepsis/, 8 Jul 2017. Accessed 19 Mar. 2018.
3. Kumar G, Kumar N, Taneja A et al. "Nationwide Trends of Severe Sepsis in the Twenty First Century (2000–2007)." Chest, vol. 16. 2011, pp. 1223–31. doi: 10.1378/chest.11-0352.
4. Hall MJ, Williams SJ, DeFrances CJ, Golosinsky A. "Inpatient Care for Septicemia or Sepsis: A Challenge for Patients and Hospitals." ww.cdc.gov/nchs/data/databriefs/db62.pdf, June 2011. Accessed 2 May 2018.
5. Perman SM, Goyal M, Gaieski DF. "Initial Emergency Department Diagnosis and Management of Adult Patients with Severe Sepsis and Septic Shock." Scand J Trauma Resusc Emerg Med, 20, 41. 2012. doi.org/10.1186/1757-7241-20-41
6. Torio C, Moore B. “National Inpatient Hospital Costs: The Most Expensive Conditions by Payer.” www.hcup-us.ahrq.gov/reports/statbriefs/sb204-Most-Expensive-Hospital-Conditions.pdf, May 2016. Accessed 15 Jan. 2018.
7. Angus, DC et al. “Epidemiology of Severe Sepsis in the United States: Analysis of Incidence, Outcome, and Associated Costs of Care.” Crit Care Med, vol. 29. 2001, pp. 1303–10.
8. Fingar K. “Trends in Hospital Readmissions for Four High-volume Conditions, 2009–2013.” www.hcup-us.ahrq.gov/reports/statbriefs/sb196-Readmissions-Trends-High-Volume-Conditions.jsp, November 2015. Accessed 15 Jan. 2018.
9. Kumar A, Roberts D, Wood KE et al. “Duration of Hypotension Before Initiation of Effective Antimicrobial Therapy is the Critical Determinant of Survival in Human Septic Shock.” Crit Care Med, vol. 34, no. 6. 2006, pp. 1589–96. 
10. Jones SL et al. “Reductions in Sepsis Mortality and Costs After Design and Implementation of a Nurse-based Early Recognition and Response Program.” Jt Comm J Qual Patient Saf, vol. 41, no. 11. 2015, pp. 483–91.
11. Judd WR, Stephens DM, Kennedy DA. “Clinical and Economic Impact of a Quality Improvement Initiative to Enhance Early Recognition and Treatment of Sepsis.” Ann Pharmacol, vol. 48, no. 10. 2014, pp. 1269–75.