Early Sepsis Detection

The global healthcare impact of sepsis

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis is a global healthcare crisis, affecting over 30 million people worldwide each year.1 The occurrence of sepsis is increasing at an annual rate of 1.5%, making it a significant global healthcare concern. Sepsis has a high mortality rate, killing more individuals than prostate cancer, breast cancer and HIV/AIDS combined.2,3,4 

In addition to the human toll, sepsis is costly to healthcare organizations. Sepsis-related costs—which may include longer hospital stays, ICU admissions, hospital readmissions, and extensive testing and patient monitoring—surpass $24 billion.

Sepsis by Numbers infographic

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Early sepsis detection and treatment can save lives 

Mortality from sepsis is decreased by 7.6% per hour by the early and appropriate administration of antibiotics.9 Early identification and treatment of sepsis can also reduce the cost of sepsis-related care.10,11

Emergency department (ED) clinicians play a unique role as the first line of care for acutely ill patients. While the ability to triage patients, identify sepsis and initiate treatment is vitally important, diagnosing sepsis remains a challenge. Symptoms are often unclear and unspecific, such that sepsis is often overlooked or recognized too late.

Know sooner with the Early Sepsis Indicator

The Early Sepsis Indicator, together with other laboratory findings and clinical information, provides clinicians with an alert as to the possibility of sepsis or risk of developing sepsis in adult patients entering the ED, prompting the initiation of treatment.   

  • Receive clinically relevant answers, sooner. Results are reported as part of the initial CBC with differential test, which is available in less than 60 minutes in a typical ED. This can provide an earlier alert to possible sepsis or developing sepsis when added to the current standard of care
  • Enable earlier initiation of treatment. By rapidly delivering answers to ED clinicians, the Early Sepsis Indicator can potentially provide an alert to sepsis before clinical symptoms are clear
  • Obtain results without added workflow burden. The Early Sepsis Indicator is part of routine blood work, so there is no additional test to order or analysis effort required

Supporting Early Sepsis Detection 

Discover important information supporting early sepsis detection and timely patient care

The Role of Monocytes in the Progression of Sepsis

Monocytes perform multiple immunological functions and play a role in immune response to sepsis. By measuring monocyte morphological changes, the Early Sepsis Indicator can aid clinicians in making clinical decisions related to sepsis for better-targeted treatment. 

Improved Early Detection of Sepsis in the ED 

"Sepsis most often presents to the ED, and delayed detection is harmful. WBC count is often used to detect sepsis, but changes in WBC count size also correspond to sepsis. We sought to determine if volume increases of circulating immune cells add value to the WBC count for early sepsis detection in the ED."

Get Answers with the ESCAVO Sepsis Clinical Guide app

The top-ranked app on the topic of sepsis, the ESCAVO Sepsis Clinical Guide is a medical reference mobile app for healthcare professionals managing patients in the acute-care setting. Download the guide to access the latest research material in a user-friendly format, putting the most current clinical practice guidelines in their hands at the point of care.

DxH 900 hematology analzyer

Available on the DxH 900 Analyzer

The Early Sepsis Indicator uses the DxH 900 hematology analyzer’s unique VCS 360 technology, which characterizes cells, including monocytes, in their near-native states. Monocytes play a role in the dysregulated immune response to sepsis, and identifying morphological changes provides insight into possible sepsis earlier than other indicators. 

Learn more

Additional Resource

For more information about sepsis, visit Global Sepsis Alliance
Global Sepsis Alliance


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1. Sepsis Alliance. “Fact Sheet.2018.” Sepsis.org. Accessed 6 Mar. 2019.
2. Vidant Beaufort Hospital “The Third-leading Cause of Death: Sepsis” www.thewashingtondailynews.com/2017/07/08/the-third-leading-cause-of-death-sepsis/, 8 Jul 2017. Accessed 19 Mar. 2018.
3. Kumar G, Kumar N, Taneja A et al. "Nationwide Trends of Severe Sepsis in the Twenty First Century (2000–2007)." Chest, vol. 16. 2011, pp. 1223–31. doi: 10.1378/chest.11-0352.
4. Hall MJ, Williams SJ, DeFrances CJ, Golosinsky A. "Inpatient Care for Septicemia or Sepsis: A Challenge for Patients and Hospitals." ww.cdc.gov/nchs/data/databriefs/db62.pdf, June 2011. Accessed 2 May 2018.
5. Perman SM, Goyal M, Gaieski DF. "Initial Emergency Department Diagnosis and Management of Adult Patients with Severe Sepsis and Septic Shock." Scand J Trauma Resusc Emerg Med, 20, 41. 2012. doi.org/10.1186/1757-7241-20-41
6. Torio C, Moore B. “National Inpatient Hospital Costs: The Most Expensive Conditions by Payer.” www.hcup-us.ahrq.gov/reports/statbriefs/sb204-Most-Expensive-Hospital-Conditions.pdf, May 2016. Accessed 15 Jan. 2018.
7. Angus, DC et al. “Epidemiology of Severe Sepsis in the United States: Analysis of Incidence, Outcome, and Associated Costs of Care.” Crit Care Med, vol. 29. 2001, pp. 1303–10.
8. Fingar K. “Trends in Hospital Readmissions for Four High-volume Conditions, 2009–2013.” www.hcup-us.ahrq.gov/reports/statbriefs/sb196-Readmissions-Trends-High-Volume-Conditions.jsp, November 2015. Accessed 15 Jan. 2018.
9. Kumar A, Roberts D, Wood KE et al. “Duration of Hypotension Before Initiation of Effective Antimicrobial Therapy is the Critical Determinant of Survival in Human Septic Shock.” Crit Care Med, vol. 34, no. 6. 2006, pp. 1589–96. 
10. Jones SL et al. “Reductions in Sepsis Mortality and Costs After Design and Implementation of a Nurse-based Early Recognition and Response Program.” Jt Comm J Qual Patient Saf, vol. 41, no. 11. 2015, pp. 483–91.
11. Judd WR, Stephens DM, Kennedy DA. “Clinical and Economic Impact of a Quality Improvement Initiative to Enhance Early Recognition and Treatment of Sepsis.” Ann Pharmacol, vol. 48, no. 10. 2014, pp. 1269–75.