Monocyte Distribution Width
Monocyte Distribution Width (MDW), proprietary to Beckman Coulter analyzers, is the only regulatory-cleared hematological biomarker that helps to establish severity of infection and risk of sepsis in adult patients in the emergency department. MDW is a measure of increased morphological variability of monocytes in response to bacterial, viral or fungal infections.
MDW is reported automatically as part of a routine CBC with Differential test on the DxH 900 and DxH 690T hematology analyzers using the Early Sepsis Indicator (ESId) application*, which enables automatic reporting with no workflow changes or need to order an additional test.
Add Value to Your Emergency Department’s Triage Protocol with MDW
MDW, proprietary to Beckman Coulter analyzers, is the only FDA-cleared hematological biomarker that helps to establish severity of infection and risk of sepsis in adult patients in the ED.
MDW helps reduce diagnostic uncertainty. It is available early to help clinicians escalate or de-escalate care in patients with suspected infectious etiology.
MDW is available early in patient assessments as part of CBC with Differential tests—no need to order additional tests.
MDW Patient Case Studies
T-47 Minutes to Antibiotics Administration
MDW biomarker identified a risk of severe infection and reclassified the patient into higher acuity category in conjunction with current standard of care.View case study
Abnormal MDW 27.3 Changed Patient’s Trajectory
The inclusion of MDW in the clinical thought process helped physicians to uncover an underlying infection which could have otherwise been missed leading to inappropriate therapeutic interventions.View case study
Sepsis Diagnosis: Saving 85 Minutes to Start Abx
Learn how elevated MDW along with clinical correlation prompted a sepsis diagnosis and helped eliminate 85 minutes of source control, allowing for prompt antibiotic administration.View case study
BLOG What is Monocyte Distribution Width?
A large unmet clinical need for the early detection of sepsis exists. MDW is a novel, FDA-cleared biomarker intended to meet this need.
Peer-Reviewed Clinical Study MDW Improves SIRS and qSOFA Early Sepsis Detection in the Emergency Department
New analysis from a pivotal study shows that patients with abnormal MDW values at presentation have increased odds of sepsis.
Webinar The Science Behind Early Sepsis Indicator: Why Do Monocytes Matter?
Learn how monocytes contribute to the development of sepsis and discover the scientific evidence behind MDW.
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- A. Vijayan et al., Procalcitonin: A Promising Diagnostic Marker for Sepsis and Antibiotic Therapy, Journal of Intensive Care 2017; 5:51. https://doi.org/10.1186/s40560-017-0246-8
- M. Filbin et al., Presenting Symptoms Independently Predict Mortality in Septic Shock: Importance of a Previously Unmeasured Confounder, Critical Care Medicine 2018; 46(10), 1592-1599. https://doi.org/10.1097/ccm.0000000000003260
- UniCel DxH 900 Coulter Cellular Analysis System Early Sepsis Indicator (ESId) Application Addendum PN C42014AC April 2020
- E. Piva et al., Monocyte Distribution Width (MDW) Parameter as a Sepsis Indicator in Intensive Care Units, Clin Chem Lab Med 2021. https://doi.org/10.1515/cclm-2021-0192
- P. Hausfater et al., Monocyte Distribution Width (MDW) Performance as an Early Sepsis Indicator in the Emergency Department: Comparison with CRP and Procalcitonin in a Multicenter International European Prospective Study, Crit Care 2021; 25, 227. https://doi.org/10.1186/s13054-021-03622-5
- A. Woo et al., Monocyte Distribution Width Compared with C-Reactive Protein and Procalcitonin for Early Sepsis Detection in the Emergency Department, PLoS ONE 2021; 16(4): e0250101. https://doi.org/10.1371/journal.pone.0250101
- H. Lin et al., Clinical Impact of Monocyte Distribution Width and Neutrophil-to-Lymphocyte Ratio for Distinguishing COVID-19 and Influenza from Other Upper Respiratory Tract Infections: A Pilot Study, PLoS ONE 2020 15(11): e0241262. https://doi.org/10.1371/journal.pone.0241262
- L. Agnello et al., Monocyte Distribution Width (MDW) as a Screening Tool for Sepsis in the Emergency Department, Clin Chem Lab Med 2020; 58(11):1951-1957. https://doi:10.1515/cclm-2020-0417
- G. Riva et al., Monocyte Distribution Width (MDW) as Novel Inflammatory Marker with Prognostic Significance in COVID‑19 Patients, Scientific Report 2021; 11:12716. https://doi.org/10.1038/s41598-021-92236-6
- Marcos-Morales, A et al., Elevated monocyte distribution width in trauma: An early cellular biomarker of organ dysfunction, Injury 2021; S0020-1383(21):00933-00935. https://doi.org/10.1016/j.injury.2021.11.026
- E. Crouser et al., Monocyte Distribution Width: A Novel Indicator of Sepsis-2 and Sepsis-3 in High-Risk Emergency Department Patients, Critical Care Med 2019; 47:1018-1025. https://doi.org/10.1097/CCM.0000000000003799
- E. Crouser et al., Improved Early Detection of Sepsis in the ED with a Novel Monocyte Distribution Width Biomarker, CHEST 2017; 152(3):518-526. https://doi.org/10.1016/j.chest.2017.05.039
- A. Ognibene et al., Elevated Monocyte Distribution Width in COVID-19 Patients: The Contribution of the Novel Sepsis Indicator, Clinica Chimica Acta 2020; 509: 22-24. https://doi.org/10.1016/j.cca.2020.06.002