Accurate platelet measurement is essential for guiding treatment decisions in patients with thrombocytopenia and other hematologic disorders. Laboratories need consistent, reliable results across the full range of platelet counts, including critically low levels, while maintaining efficiency and controlling costs.

A study performed by researchers at the Hospital Universitari Germans Trias i Pujol in Badalona, Spain, compared the platelet counting performance of the Beckman Coulter DxH 900 and the Mindray BC-6800 Plus analyzers against the ICSH-recommended flow cytometry reference method. A total of 104 patient samples, ranging from 4 × 10⁹/L to 1135 × 10⁹/L, were evaluated using each analyzer’s standard technologies and EDTA-collected samples.

The study found:

• Excellent overall correlation with flow cytometry (DxH 900 r = 0.989; BC-6800 Plus r = 0.987).
• Strong agreement in samples with platelet counts below 50 × 10⁹/L (DxH 900 r = 0.928; BC-6800 Plus r = 0.954).
• Good correlation maintained even below 20 × 10⁹/L (DxH 900 r = 0.816; BC-6800 Plus r = 0.875).
• Direct comparison between analyzers showed very high agreement (r = 0.993).

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