Monocyte Distribution Width

Only regulatory-cleared hematology-based cellular biomarker

Help emergency department physicians identify patients with severe infection leading to sepsis with Monocyte Distribution Width (MDW). MDW is a measure of increased morphological variability of monocytes in response to bacterial, viral or fungal infections.

The quantitative analysis of MDW by hematology analyzers using Early Sepsis Indicator (ESId) application received regulatory clearances as a hematology biomarker for sepsis to support prompt clinical decision making for this often-deadly condition. This parameter is reported automatically as part of a routine CBC with differential on the DxH 900 and DxH 690T hematology analyzers,* enabling automatic reporting without added workload burden.

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Sepsis is difficult to diagnose, with over 30% of septic shock patients presenting vague symptoms that might be missed by EMR alerts.¹

With MDW, institutions can support better sepsis-related patient care through earlier recognition. MDW is unique, compared to other sepsis markers, as it measures morphological changes in monocytes—cells that play a role in the immune system’s early response to infection.

Monocytes change size and shape in response to infection. By measuring MDW as a marker for sepsis, this lab test for sepsis can inform clinical decision making earlier.

Add value to your institution’s sepsis identification protocol with MDW

Offer the only regulatory-cleared hematology parameter for sepsis
Report results automatically as part of the CBC with differential for adult patients in the emergency department with the optional sepsis parameter

MDW has been shown in clinical trials and practice to drive clinical decisions for patients at risk of sepsis and severe infection.

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Early Sepsis Indictor Toolbox

Monocyte Distribution Width (MDW) sepsis biomarker is a measure of increased morphological variability of monocytes in response to bacterial, viral or fungal infections. The quantitative analysis of MDW by hematology analyzers using Early Sepsis Indicator (ESId) application received regulatory clearances as an aid for early detection in adult patients with or developing sepsis in emergency department.

MDW is automatically reported with the complete blood count (CBC) with differential* for adult emergency department patients. As quickly as the CBC with diff gets reported to the emergency department, you now have this additional objective data point to assist in faster patient triage. This ESId Toolbox features clinical education on-demand webinar reviewing the clinical evidence and performance of MDW for sepsis detection.

Clinical Utility of a Novel Sepsis Biomarker

Webinar Monocyte Distribution Width (MDW): novel sepsis biomarker in Emergency Department

In this webinar, Dr Steve Ness describes clinical utility of MDW for the early detection of sepsis.

Watch now

*Using Early Sepsis Indicator application on Beckman Coulter DxH 900 and DxH 690T hematology analyzers. Activation is required.

1. UniCel DxH 900 Coulter Cellular Analysis System Early Sepsis Indicator (ESId) Application Addendum PN C42014AA

MDW Patient Case Studies

T-47 Minutes to Antibiotics Administration

MDW biomarker identified a risk of severe infection and reclassified the patient into higher acuity category, in conjunction with current standard of care.

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T-47 Minutes to Antibiotics Administration-450x450

Abnormal MDW 27.3 Changed Patient’s Trajectory

The inclusion of monocyte distribution width (MDW) biomarker in clinical thought process helped physicians to uncover an underlying infection, that could have otherwise been missed, leading to inappropriate therapeutic interventions. We can prevent sepsis by preventing evolution of infection to sepsis.

View case study

Abnormal MDW 27.3 Changed Patient’s Trajectory-450x450

Sepsis detection in the emergency department

Blog What is Monocyte Distribution Width?

A large unmet clinical need for the early detection of sepsis exists. MDW is a novel FDA-cleared biomarker intended to meet this need.

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Peer-Reviewed Clinical Study MDW Aids Early Sepsis Detection in the Emergency Department Beyond SIRS and qSOFA

New analysis from the pivotal study shows that patients with abnormal values of MDW at presentation have increased odds of sepsis.

Read study

Webinar The Science Behind Early Sepsis Indicator: Why Do Monocytes Matter?

Learn how monocytes contribute to the development of sepsis and discover the scientific evidence behind a novel sepsis biomarker MDW.

View on demand

*Activation is required.

REMISOL Advance is a trademark or registered trademark of Normand-Info SAS in the United States and other countries. Used under license.

1. Filbin, M. R., Lynch, J., Gillingham, T. D., Thorsen, J. E., Pasakarnis, C. L., Nepal, S., et al. Presenting Symptoms Independently Predict Mortality in Septic Shock. Critical Care Medicine, 2018; 46(10), 1592-1599. https://doi.org/10.1097/ccm.0000000000003260.

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