Access PCT Advances Patient Care with Optimized Laboratory Workflows
Provide confidence in results and improve patient care through:
- >95% overall agreement with predicate method for accurate assessment of patients at risk of progression to severe sepsis and septic shock
- State-of-the art sensitivity and low-end precision―20% CV LoQ of 0.02 ng/mL and CV ≤8% at concentrations of ≥0.150 ng/mL
- Rapid access to results with first result in approximately 20 minutes
- Minimal sample draw of 35 µl pick-up volume
|Platform||Correlation (r)||Overall agreement @ 0.5 ng/mL||Overall agreement @ 2.0 ng/mL|
|VIDAS® B·R·A·H·M·S PCT® (n=260)†||0.98||96.5%||99.2%|
|ARCHITECT® B·R·A·H·M·S PCT® (n=257)†||0.99||97.7%||95.3%|
|ELECSYS® B·R·A·H·M·S PCT® (n=260)†||0.99||98.1%||91.9%|
Simplify sample processing and reduce separate PCT analysis workstation costs with:
- Random-access, high-throughput systems with >65 available assays and 50 reagent pack positions
- Fewer manual processing steps compared to standalone systems
- Onboard reagent storage of liquid, ready-to-use, 50-test reagent packs
- 42-day calibration stability
What is the Connection between Procalcitonin and Infections?
The procalcitonin amino acid peptide is a precursor of calcitonin. In healthy individuals, procalcitonin (PCT) levels are typically less than 0.1 ng/mL.1 In individuals with inflammation or infections, PCT levels rise in circulation in response to inflammatory cytokines and bacterial endotoxins.
How is Procalcitonin Used as a Risk Assessment Tool for Sepsis?
PCT levels correlate with the severity of bacterial infections and the probability of a positive blood culture. That makes it a clinically useful diagnostic marker in the assessment of patients with suspected sepsis or life-threatening septic shock.2,3,4
PCT blood tests can aid in differentiating between sepsis of viral or bacterial origin. PCT tests also support monitoring the course and severity of a sepsis systemic inflammatory response.
How Can Clinicians Use Procalcitonin for the Risk Assessment for Sepsis?
PCT levels less than 0.5 ng/mL do not exclude local or systemic infections in their initial stages (under 6 hours). Consider the patient’s history when interpreting PCT levels between 0.5 and 2.0 ng/mL. Retesting PCT within 6 to 24 hours is recommended if any levels are less than 2.0 ng/mL.5