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Hematology-based Cellular Biomarker in the Emergency Department
Monocyte Distribution Width (MDW) is a measure of increased morphological variability of monocytes in response to bacterial, viral or fungal infections. The quantitative analysis of MDW has received regulatory clearance to help emergency department physicians identify patients with severe infection leading to sepsis.
Considered with other signs and symptoms, the value of MDW helps differentiate sepsis from non-septic presentations, including non-infectious systemic inflammatory response.4 This parameter is automatically reported with the complete blood count (CBC) with differential on the DxH 900 and DxH 690T hematology analyzers*, enabling automatic reporting without added workload burden.
Key Findings from Journal of Intensive Care Study The performance of MDW for sepsis detection has been evaluated in the prospective observational study of 2,158 emergency department patients in three large academic centers.
Diagnostic Performance for Sepsis Detection
Considering MDW together with WBC, MDW may add to the sensitivity and specificity of sepsis detection, as part of the standard assessment protocol in the emergency department.4,5
MDW in Patients with "Gray Zone" Symptoms
Diagnostic uncertainty is a major challenge for patients presenting to the emergency department with a low number of signs and symptoms.
MDW Modulates the Probability of Sepsis
When considered with the standard physiologic parameters at the time of patient presentation, abnormal values of MDW signify a 4-6x increase in probability of sepsis diagnosis.
Additional MDW Patient Case Studies
T-47 Minutes to Antibiotics Administration
MDW biomarker identified a risk of severe infection and reclassified the patient into higher acuity category, in conjunction with current standard of care.
Abnormal MDW 27.3 Changed Patient’s Trajectory
The inclusion of monocyte distribution width (MDW) biomarker in clinical thought process helped physicians to uncover an underlying infection, that could have otherwise been missed, leading to inappropriate therapeutic interventions. We can prevent sepsis by preventing evolution of infection to sepsis.
Latest Scientific Presentations
Watch ISICEM 2021 symposium recording to hear Profs. Jean-Louis Vincent, Pierre Hausfater and Fernando Arméstar Rodríguez discussion on MDW and the latest clinical evidence for its utility to detect severe infection and risk of sepsis. View on demand ›
Watch the latest ACEP20 recording where Dr. Osborn and Dr. Hausfater review the current state of clinical evidence for MDW derived from the series of multicenter studies and discuss the practical implications of these results to the U.S. and European standards of sepsis care. Watch recording ›
View the webinar, hosted by Sepsis Alliance, to hear Angela D. Craig, APN, M.S., CCNS from Cookeville Regional Medical Center and Dustin Pierce, RN, BSN, CPHQ from University of Kansas Hospital discuss standards of sepsis care, review challenges with protocols and examine the clinical evidence and utility of MDW. Watch recording ›
Watch the ISLH 2021 on-demand workshop to hear Dr. Czader, Indiana University, and Dr. Morales, University Hospital Germans Trias i Pujol, discuss the role of monocytes and neutrophils in innate immune response to infection, monocytes morphology in clinical decision-making and present emerging evidence based on multicentric European clinical trials. Watch recording >
The value of MDW is that it provides physicians with an earlier indication of sepsis during the initial encounter, which is especially important when a patient’s symptoms are mild and alternative diagnosis are being considered.
Ohio State University Wexner Medical Center
Learn More About Early Sepsis Detection
View clinical studies, scientific presentations, white papers and the latest webinars that review the clinical utility of MDW.
Peer-Reviewed Clinical Study Critical Care Medicine Study
Discover how a multicenter study validated MDW as a novel indicator for Sepsis-2 and Sepsis-3 in high-risk emergency department patients.
Read study
Video MDW Clinician Training
In this clinician training video Dr. Steve Ness will walk you through the clinical utility of MDW and explain the potential benefits of using the biomarker to aid in early sepsis detection for patients in your emergency department.
Watch videoAdditional Resources
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*Using Early Sepsis Indicator application on Beckman Coulter DxH 900 and DxH 690T analyzers. Activation is required.
3Filbin, M. R., Lynch, J., Gillingham, T. D., Thorsen, J. E., Pasakarnis, C. L., Nepal, S., et al. Presenting Symptoms Independently Predict Mortality in Septic Shock. Critical Care Medicine, 2018; 46(10), 1592-1599. https://doi.org/10.1097/ccm.0000000000003260.
4UniCel DxH 900 Coulter Cellular Analysis System Early Sepsis Indicator (ESId) Application AddendumPN C42014AA.
5Sepsis Pivotal Repository PN C54726 Rev. AB located in CPDM.
6Crouser, E. D., Parrillo, J. E., Martin, G. S., Huang, D. T., Hausfater, P., Grigorov, I., Careaga, D., Osborn, T., Hasan, M, Tejidor, L. Monocyte Distribution Width Enhances Early Sepsis Detection in the Emergency Department Beyond SIRS and qSOFA. Journal of Intensive Care, 2020; 8(1). https://doi.org/10.1186/s40560-020-00446-3.
