Hematology-based Cellular Biomarker in the Emergency Department
Monocyte Distribution Width (MDW) is a measure of increased morphological variability of monocytes in response to bacterial, viral or fungal infections. The quantitative analysis of MDW has received regulatory clearance to help emergency department physicians identify patients with severe infection leading to sepsis.
Considered with other signs and symptoms, the value of MDW helps differentiate sepsis from non-septic presentations, including non-infectious systemic inflammatory response.4 This parameter is automatically reported with the complete blood count (CBC) with differential on the DxH 900 and DxH 690T hematology analyzers*, enabling automatic reporting without added workload burden.
Key Findings from Journal of Intensive Care Study The performance of MDW for sepsis detection has been evaluated in the prospective observational study of 2,158 emergency department patients in three large academic centers.
Diagnostic Performance for Sepsis Detection
Considering MDW together with WBC, MDW may add to the sensitivity and specificity of sepsis detection, as part of the standard assessment protocol in the emergency department.4,5
MDW in Patients with "Gray Zone" Symptoms
Diagnostic uncertainty is a major challenge for patients presenting to the emergency department with a low number of signs and symptoms.
MDW Modulates the Probability of Sepsis
When considered with the standard physiologic parameters at the time of patient presentation, abnormal values of MDW signify a 4-6x increase in probability of sepsis diagnosis.
Additional MDW Patient Case Studies
T-47 Minutes to Antibiotics Administration
MDW biomarker identified a risk of severe infection and reclassified the patient into higher acuity category in conjunction with current standard of care.
Abnormal MDW 27.3 Changed Patient’s Trajectory
The inclusion of monocyte distribution width (MDW) biomarker in the clinical thought process helped physicians to uncover an underlying infection which could have otherwise been missed leading to inappropriate therapeutic interventions. We can prevent sepsis by preventing evolution of infection to sepsis.
Latest Scientific Presentations
Watch ISICEM 2021 symposium recording to hear Profs. Jean-Louis Vincent, Pierre Hausfater and Fernando Arméstar Rodríguez discussion on MDW and the latest clinical evidence for its utility to detect severe infection and risk of sepsis. View on demand ›
Learn More About Early Sepsis Detection
View clinical studies, scientific presentations, white papers and the latest webinars that review the clinical utility of MDW.
Peer-Reviewed Clinical Study Critical Care Medicine Study
Discover how a multicenter study validated MDW as a novel indicator for Sepsis-2 and Sepsis-3 in high-risk emergency department patients.Read study
*Using Early Sepsis Indicator application on Beckman Coulter DxH 900 and DxH 690T analyzers. Activation is required.
3Filbin, M. R., Lynch, J., Gillingham, T. D., Thorsen, J. E., Pasakarnis, C. L., Nepal, S., et al. Presenting Symptoms Independently Predict Mortality in Septic Shock. Critical Care Medicine, 2018; 46(10), 1592-1599. https://doi.org/10.1097/ccm.0000000000003260.
4UniCel DxH 900 Coulter Cellular Analysis System Early Sepsis Indicator (ESId) Application AddendumPN C42014AA.
5Sepsis Pivotal Repository PN C54726 Rev. AB located in CPDM.
6Crouser, E. D., Parrillo, J. E., Martin, G. S., Huang, D. T., Hausfater, P., Grigorov, I., Careaga, D., Osborn, T., Hasan, M, Tejidor, L. Monocyte Distribution Width Enhances Early Sepsis Detection in the Emergency Department Beyond SIRS and qSOFA. Journal of Intensive Care, 2020; 8(1). https://doi.org/10.1186/s40560-020-00446-3.