In vitro Diagnostic (IVD) hematology parameters can be used to aid in monitoring disease progression and treatment. MPV, MRV and MDW are regulatory-cleared IVD tests that provide information to aid in patient management. From anemias to leukemias and multiple myeloma to sepsis, clinicians rely on these IVD parameters to provide the best possible treatment for their patients.
*In Vitro Diagnostic parameters. For use in In Vitro Diagnostic procedures.
What is the MPV Parameter?
How is MPV used?
Mean Platelet Volume: Unlike platelet counts, which measure the number of circulating platelets, MPV measures the average size of platelets. Platelet size may change in response to certain diseases such as lupus and thyroid disorders. Platelet size is also important in determining the underlying cause of abnormal platelet count. And because younger platelets tend to be larger than older platelets, MPV can be used to gauge platelet age, which can further aid in disease diagnosis.3
What is the MDW Parameter?
How is MDW used?
Monocyte Distribution Width: The MDW parameter reflects a change in the volume of circulating monocytes in response to pro-inflammatory signals from infectious organisms referred to as pathogen-associated molecular patterns (PAMPs). Importantly, the results of MDW are independent of monocytes subpopulation percentage. The MDW value can be assessed simultaneously with the WBC value to provide physicians additional information regarding a patient’s immune status in response to infection.8-19
*For COVID-19 use in the EU only.
For MDW specific performance claims, please refer to UniCel DxH 900 Coulter Cellular Analysis System Early Sepsis Indicator (ESId) Application Addendum PN C42014AC.
MDW values greater than 20.0 together with other laboratory findings and clinical information, aids in identifying patients with sepsis or at increased risk of developing sepsis within the first 12 hours of hospital admission.
MDW results greater than 20.0 should be interpreted in association with other clinical information and diagnostic testing as a proportion of patients without sepsis may have an elevated MDW value at baseline. MDW values less than or equal to 20.0 cannot rule out sepsis or the development of sepsis within 12 hours of hospital admission. The Early Sepsis Indicator should not be used as the sole basis to determine the absence of sepsis.
What is the MRV Parameter?
How is MRV used?
Mean Reticulocyte Volume: MRV represents the average volume of all reticulocytes. It is a reticulocyte characteristic that can be used to determine therapeutic effects on certain blood diseases. For example, MRV has been shown to increase in anemia patients with chronic kidney disease following intravenous iron therapy.32 However, following B12 treatment of patients with macrocytic anemia, MRV was shown to decrease.32 MRV is also used as a specific parameter to screen for hereditary spherocytosis, an inherited anemia that tends to result in lower MRV, and immune hemolytic anemia, an autoimmune disorder that tends to result in higher MRV.33
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8. Riva, G. (2021). Monocyte Distribution Width (MDW) as novel inflammatory marker with prognostic significance in COVID-19 patients. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-92236-6
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20. Lazarova E. et al. (2014). Automated reticulocyte parameters for hereditary spherocytosis screening. Annals of Hematology, 93(11), 1809–1818. https://doi.org/10.1007/s00277-014-2127-8
21. Nair, S. (2015). Mean reticulocyte volume enhances the utility of red cell mean sphered cell volume in differentiating peripheral blood spherocytes of hereditary spherocytosis from other causes. Indian Journal of Pathology and Microbiology, 58(3), 307. https://doi.org/10.4103/0377-4929.162836
22. Xu, Y. et al. (2015). Mean reticulocyte volume: a specific parameter to screen for hereditary spherocytosis. European Journal of Haematology, 96(2), 170–174. https://doi.org/10.1111/ejh.12563
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