New analysis of a pivotal study of 2,158 patients at three leading academic centers sought to determine if monocyte distribution width (MDW), a new sepsis biomarker, can aid in early sepsis detection in adult patients with present or developing sepsis symptoms in the emergency department.
The study determined that, when considered along with the standard physiologic parameters at the time of patient presentation, abnormal values of MDW signify a 4-6x increase in probability of sepsis diagnosis. In patients with a low level of symptoms and highest diagnostic uncertainty at presentation, abnormal MDW increased the odds of sepsis by ~3x.1
Peer-Reviewed Clinical Study MDW Improves SIRS and qSOFA Early Sepsis Detection in the Emergency Department
New analysis from a pivotal study shows that patients with abnormal MDW values at presentation have increased odds of sepsis.Read study
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1. Crouser, E. D., Parrillo, J. E., Martin, G. S., Huang, D. T., Hausfater, P., Grigorov, I., Tejidor, L. (2020). Monocyte distribution width enhances early sepsis detection in the emergency department beyond SIRS and qSOFA. Journal of Intensive Care, 8(1). doi:10.1186/s40560-020-00446-3