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CHEMISTRY
Antipsychotic Drug Monitoring
It’s time for rapid and accurate results.
Your Questions Answered
Antipsychotic drugs are used to manage and treat symptoms of psychosis. Schizophrenia and bipolar disorder are two common mental illnesses for which antipsychotic medications may be prescribed.
Serious mental illness (SMI) – a mental, behavioral or emotional disorder that severely impairs an individual’s ability to function – is a significant public health concern. Antipsychotic drugs are often prescribed to those with SMI. There is a great need to monitor antipsychotic drug blood levels for those with SMI to ensure they are receiving the best possible care.
Prevalence and Economic Burden of Serious Mental Illnesses (SMI)
Antipsychotic drug monitoring provides healthcare professionals accurate, vital information to help manage their patients’ therapy. Antipsychotic medications in addition to other psychotherapies may help to reduce the intensity and frequency of psychotic symptoms. Patients with untreated schizophrenia4 or bipolar5 may experience increased intensity of symptoms which could be disabling, potentially resulting in additional medical care or could lead to suicide.
Until now, the vital information that antipsychotic drug monitoring assays provide was not readily available to help healthcare professionals manage their patients’ therapy. With antipsychotic drug monitoring, critical information is available when and where it’s most needed.
The need for timely results:
Current methods take days to provide test results. However, rapid antipsychotic therapeutic drug management can return results in 15 minutes or less.
The need for accurate results:
Common assessments of medication status are frequently misleading. A blinded study6 found clinicians had an accuracy rate of only 41% in predicting therapeutic levels compared to diagnostic testing.
Antipsychotic drug monitoring assays run on automated (AU) clinical analyzers, including AU480, AU680 and AU5800 in clinical laboratories.
We’re committed to elevating our therapeutic drug monitoring menu to support clinicians in aiding, monitoring and treating patients with serious mental illnesses. We recognize the need for healthcare providers to be equipped with quantitative insights to manage patient therapy. In partnership with Saladax, we’re addressing that significant, unmet need by providing rapid, low-cost and accurate antipsychotic drug blood level monitoring assays.
Click here to learn more about our full therapeutic drug monitoring, testing and detection menu.
Six drugs can be tested through the five available assays†. These assays address a significant unmet clinical need for patients with SMI by providing healthcare professionals a rapid, low-cost, and accurate antipsychotic drug blood level.
| Drug Name | Brand Name | Prescribed for | FDA Approved | CE Marked |
| Clozapine | Clozaril | Schizophrenia, schizoaffective disorder | Yes | Yes |
| Risperidone or Paliperidone |
Risperdal or Invega |
Schizophrenia, Bipolar Mania, irritability associated with autistic disorder (Risperidone); schizophrenia, schizoaffective disorder (paliperidone) | Yes | |
| Aripiprazole | Abilify | Schizophrenia, bipolar disorder | Yes | |
| Quetiapine | Seroquel | Schizophrenia, bipolar disorder, adjunctive treatment of major depressive disorder (MDD) | Yes | |
| Olanzapine | Zyprexa | Schizophrenia, bipolar disorder | Yes |
†These products may not be available in your country or region at this time. Please fill out the form and we can follow up with you appropriately.
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"Lack of adherence among patients with schizophrenia is associated with increased rates of hospitalization. Identifying problems in adherence prior to symptomatic worsening can lead to fewer hospitalizations and improve clinical outcomes. Therapeutic drug monitoring can improve patient outcomes by avoiding unnecessary dose escalations, reducing adverse drug reactions and facilitating the switch to alternative therapies when appropriate. All of these potential benefits ultimately improve patient outcomes and lead to more cost-effective care."
Director of Medical and Scientific Affairs
Beckman Coulter Diagnostics
†These products may not be available in your country or region at this time. Please fill out the form and we can follow up with you appropriately.
Saladax is a registered trademark of Saladax Biomedical, Inc.
References:
1. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. (2018). Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet. DOI:https://doi.org/10.1016/S0140-6736(18)32279-7)
2. Transforming the Understanding and Treatment of Mental Illness. (2021). National Institute of Mental Health (NIMH). Retrieved January 26, 2022, from https://www.nimh.nih.gov/health/statistics/mental-illness
3. https://www.who.int/news-room/fact-sheets/detail/schizophrenia
4. Lopez, Leonardo V. MD*†; Shaikh, Atef DO*; Merson, Jonathan MD*†; Greenberg, Jessica MS*; Suckow, Raymond F. PhD‡; Kane, John M. MD*†§ Accuracy of Clinician Assessments of Medication Status in the Emergency Setting, Journal of Clinical Psychopharmacology: June 2017 - Volume 37 - Issue 3 - p 310-314 doi: 10.1097/JCP.0000000000000697
5. https://www.nimh.nih.gov/health/topics/schizophrenia
6. https://www.nimh.nih.gov/health/topics/bipolar-disorder#part_2264
